
Ellie is immune to the Cordyceps strain and because of this, the Fireflies, an anti-government organization, seek to reverse engineer a vaccine through her. Ellie is a brave 14-year-old girl that has grown up in this harsh world and it is all she has ever known.

The country is turned into a police state under the control of homeland security and the military, and cities across the nation are placed under martial law one by one. Survivors of the pandemic are assigned to designated quarantine zones that are supposed to separate them from the infected and keep them safe. When the World Health Organization's attempts to procure a vaccine fail, the United States government does away with the bureaucrats in power and the establishment of civilian government.

Since the outbreak, the world has gone into a state of panic and frenzy as officials try to fix and keep the situation under control. The Last of Us takes place in the year 2033, twenty years after a fungal-based, brain-altering pandemic has spread and infected over 60% of the world's population. A sequel, titled The Last of Us Part II, was revealed in December 2016 during the PlayStation Experience event. Upon release physically and digitally on July 29 and 30 that year, this version of The Last of Us came with "enhanced graphics" and included the DLC, Left Behind. On March 26, 2014, according to an interview with a Turkish Sony representative, Sercan Sulun, a PlayStation 4 version of the game, titled The Last of Us Remastered, would be released in the summer of 2014. The game was released on Jin all countries except Japan where it was released on June 20, 2013. The Last of Us was scheduled to be released on May 7, 2013, but was pushed back to six weeks. On May 15, 2013, The Last of Us had " gone gold", meaning all development of the game had been completed and mass manufacturing had begun. Set in the post-apocalyptic United States, the game tells the story of survivors Joel and Ellie as they work together to survive their westward journey across what remains of the country to find a possible cure for the modern fungal plague that has nearly decimated the entire human race.

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The game was developed by a portion of the employees at Naughty Dog, while the other half of the company went to develop Uncharted 3: Drake's Deception established for the purpose of creating new intellectual property as well as continuing the Uncharted series simultaneously. The Last of Us is a third-person action-adventure survival horror video game created exclusively for PlayStation 3, and was later remastered for the PlayStation 4.
